73 research outputs found

    Passenger transmission and productiveness of transit lines with high loads

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    Deterministic transit capacity analysis applies to planning, design and operational management of urban transit systems. The Transit Capacity and Quality of Service Manual (1) and Vuchic (2, 3) enable transit performance to be quantified and assessed using transit capacity and productive capacity. This paper further defines important productive performance measures of an individual transit service and transit line. Transit work (p-km) captures the transit task performed over distance. Passenger transmission (p-km/h) captures the passenger task delivered by service at speed. Transit productiveness (p-km/h) captures transit work performed over time. These measures are useful to operators in understanding their services’ or systems’ capabilities and passenger quality of service. This paper accounts for variability in utilized demand by passengers along a line and high passenger load conditions where passenger pass-up delay occurs. A hypothetical case study of an individual bus service’s operation demonstrates the usefulness of passenger transmission in comparing existing and growth scenarios. A hypothetical case study of a bus line’s operation during a peak hour window demonstrates the theory’s usefulness in examining the contribution of individual services to line productive performance. Scenarios may be assessed using this theory to benchmark or compare lines and segments, conditions, or consider improvements

    Involvement of (pro)renin receptor in the glomerular filtration barrier

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    (Pro)renin receptor-bound prorenin not only causes the generation of angiotensin II via the nonproteolytic activation of prorenin, it also activates the receptor’s own intracellular signaling pathways independent of the generated angiotensin II. Within the kidneys, the (pro)renin receptor is not only present in the glomerular mesangium, it is also abundant in podocytes, which play an important role in the maintenance of the glomerular filtration barrier. Recent in vivo studies have demonstrated that the overexpression of the (pro)renin receptor to a degree similar to that observed in hypertensive rat kidneys leads to slowly progressive nephropathy with proteinuria. In addition, the handle region peptide, which acts as a decoy peptide and competitively inhibits the binding of prorenin to the receptor, is more beneficial than an angiotensin-converting enzyme inhibitor with regard to alleviating proteinuria and glomerulosclerosis in experimental animal models of diabetes and essential hypertension. Thus, the (pro)renin receptor may be upregulated in podocytes under hypertensive conditions and may contribute to the breakdown of the glomerular filtration barrier

    Failure mechanisms in alloy of polyamide 6,6/polyphenylene oxide under severe conditions

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    Toughening mechanisms of a polyamide 6,6/polyphenylene oxide alloy containing an elastomer tested under a slow rate, an impact rate, and a low temperature have been investigated using various microscopy techniques. It is found that the toughening mechanisms of the alloy may change from crazing/shear yielding, to crack bridging/crazing, and to transparticle failure, depending on the testing conditions. Except for the low temperature high strain rate testing condition and in the plane stress region of the crack, the crazing mechanism has been observed in all the conditions we studied. When the testing rate is high, the shear yielding mechanism is suppressed; multiple crazing and particle bridging mechanisms appear to dominate.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44700/1/10853_2004_Article_BF00557130.pd

    Mechanical modeling of initiation of localized yielding under plane stress conditions in rigid-rigid polymer alloys

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    Two-dimensional Finite Element Method simulations, which involve consideration of the nonlinearity of a material, have been conducted to gain understanding about the rigid-rigid polymer toughening concept we proposed. The simulation results for the plane stress condition indicate that as long as the inclusion phase possesses (i) a 60% difference in the tangent modulus from that of the matrix at any given strain level prior to failure or (ii) smaller yield or craze stain than the yield strain of the matrix, then, localized shear yielding will occur around the inclusion. A toughened rigid-rigid polymer alloy system can then be obtained. The plain strain case is also discussed with an implementation of the rigid-rigid polymer toughening concept.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38110/1/760311106_ftp.pd

    Future water quality monitoring - Adapting tools to deal with mixtures of pollutants in water resource management

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    Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.Seventh Framework Programme (E.U

    The effect of a new intercity expressway based on travel time reliability using electronic toll collection data

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    This study describes a method of evaluating the level of service of road networks, based on the average travel time and travel time reliability using electronic toll collection (ETC) data. The authors focused on the variance in travel time under normal circumstances, thus, traffic accidents were removed from the database, and any effect of individual vehicle preference was excluded. They evaluated the travel time distribution based on the average travel time from ETC data for each 15-min interval. The level of service in an actual intercity highway network was analysed using the proposed method. This analysis showed that the level of service fluctuated according to the road section analysed, the month and the time of day. These findings were confirmed by the shape of the cumulative distribution and indices of average travel time and travel time reliability. Using the evaluation method described here, the analysis also confirmed the change in travel time distribution between major interchanges after the opening of a new intercity highway route. As a great change in the traffic conditions occurred, the authors analysed the relationship between traffic demand and the level of service using detector data

    High load transit line passenger transmission and productiveness efficiencies

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    Performance of urban transit systems may be quantified and assessed using transit capacity and productive capacity in planning, design and operational management activities. Bunker (4) defines important productive performance measures of an individual transit service and transit line, which are extended in this paper to quantify efficiency and operating fashion of transit services and lines. Comparison of a hypothetical bus line’s operation during a morning peak hour and daytime hour demonstrates the usefulness of productiveness efficiency and passenger transmission efficiency, passenger churn and average proportion line length traveled to the operator in understanding their services’ and lines’ productive performance, operating characteristics, and quality of service. Productiveness efficiency can flag potential pass-up activity under high load conditions, as well as ineffective resource deployment. Proportion line length traveled can directly measure operating fashion. These measures can be used to compare between lines/routes and, within a given line, various operating scenarios and time horizons to target improvements. The next research stage is investigating within-line variation using smart card passenger data and field observation of pass-ups. Insights will be used to further develop practical guidance to operators
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